Cocaine bust rumor:
Immediately after getting busted by the cops, you will hear a rumor from an inmate that there will be a cocaine bust on the next turn.
Buy the most units of cocaine possible and wait until there is a cocaine bust. Sell all of your cocaine and earn easy money. Note: This also works with heroin. Buy as much ecstasy as possible at the start of the game. Wait five days without paying pack the loan shark and hold on to your ecstasy. When you see a cop, stay and let them take your ecstasy. When you get out of jail you will have $60 million.
Fighting the cops:
Always buy as many guns as possible. The more guns you own, the easier it is to fight the cops.
Get away from cops (v2.0):
If you run into a cop, press [Shoot] to hit it exactly dead center and kill it.
You should always carry a handbook or other weapon with you. When you get chased by cops, you can hit them with it, then give up getting yourself arrested. Since there is a chance that you will hear about a bust happening the next day when you are in jail, including cocaine busts, it is actually a good thing to get arrested as long as you are not carrying a lot of expensive drugs.
Good prices for acid:
Wait for home made acid to appear on the market and buy as many as possible. Then, go to another city and find a high price. Sell them and make a huge profit.